This book provides a comprehensive overview of metabonomics and gut microbiota research from molecular analysis to population-based global health considerations. The topics include the discussion of the applications in relation to metabonomics and gut microbiota in nutritional research, in health and disease and a review of future therapeutical, nutraceutical and clinical applications. It also examines the translatability of systems biology approaches into applied clinical research and to patient health and nutrition.
The rise in multifactorial disorders, the lack of understanding of the molecular processes at play and the needs for disease prediction in asymptomatic conditions are some of the many questions that system biology approaches are well suited to address. Achieving this goal lies in our ability to model and understand the complex web of interactions between genetics, metabolism, environmental factors and gut microbiota. Being the most densely populated microbial ecosystem on earth, gut microbiota co-evolved as a key component of human biology, essentially extending the physiological definition of humans.
Major advances in microbiome research have shown that the contribution of the intestinal microbiota to the overall health status of the host has been so far underestimated. Human host gut microbial interaction is one of the most significant human health considerations of the present day with relevance for both prevention of disease via microbiota-oriented environmental protection as well as strategies for new therapeutic approaches using microbiota as targets and/or biomarkers. In many aspects, humans are not a complete and fully healthy organism without their appropriate microbiological components. Increasingly, scientific evidence identifies gut microbiota as a key biological interface between human genetics and environmental conditions encompassing nutrition. Microbiota dysbiosis or variation in metabolic activity has been associated with metabolic deregulation (e.g. obesity, inflammatory bowel disease), disease risk factor (e.g. coronary heart disease) and even the aetiology of various pathologies (e.g. autism, cancer), although causal role into impaired metabolism still needs to be established.
Metabonomics and Gut Microbiota in Nutrition and Disease serves as a handbook for postgraduate students, researchers in life sciences or health sciences, scientists in academic and industrial environments working in application areas as diverse as health, disease, nutrition, microbial research and human clinical medicine.
Table of contents :
Front Matter....Pages i-xvi
Introduction to Metabonomics in Systems Biology Research....Pages 1-24
Metabonomics in Clinical Practice....Pages 25-44
Adopting Multivariate Nonparametric Tools to Determine Genotype-Phenotype Interactions in Health and Disease....Pages 45-62
Metabonomics in Translational Research for Personalized Medicine and Nutrition....Pages 63-82
Can We Use Metabolomics to Understand Changes to Gut Microbiota Populations and Function? A Nutritional Perspective....Pages 83-108
Automated Annotation of Microbial and Human Flavonoid-Derived Metabolites....Pages 109-124
Metabonomics in Neonatal and Paediatric Research: Studying and Modulating Gut Functional Ecology for Optimal Growth and Development....Pages 125-146
Metabolomics and Milk: The Development of the Microbiota in Breastfed Infants....Pages 147-167
Metabonomics and Gut Microbial Paradigm in Healthy Aging....Pages 169-184
Roles of Herbal Medicine in Modulating Gut Microbiota Associated with Health and Diseases....Pages 185-197
Gut Microbiota and Metabolic Diseases: From Pathogenesis to Therapeutic Perspective....Pages 199-234
Role of Microbiota in Regulating Host Lipid Metabolism and Disease Risk....Pages 235-260
Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease....Pages 261-310
Deciphering the Gut Microbial Contribution to the Etiology of Autism Development....Pages 311-322
The Modulation of Drug Efficacy and Toxicity by the Gut Microbiome....Pages 323-341
Understanding the Benefits of Bariatric Surgery on Gut Physiology: Implications for Obesity, Type 2 Diabetes, and Cardiovascular Disease....Pages 343-370
Back Matter....Pages 371-375